Liara’s reference is the Athame Doctrine from the Mass Effect Game series Mass Effect is an action role-playing game developed by BioWare. It is the first game in the Mass Effect series and takes place within the Milky Way galaxy in the year 2183, where civilization is threatened by a highly advanced machine race known as the Reapers. The player assumes the role of Commander Shepard, an elite human soldier who must stop a rogue agent from carrying out the Reapers' galactic invasion. The asari, native to the planet Thessia, are often considered the most influential and respected sentient species in the galaxy and are known for their elegance, diplomacy, and biotic aptitude. The Athame Doctrine is an asari religion founded on the worship of the goddess Athame. In ancient times, Athame was a goddess of prophecy and fate, and the matriarch of the asari pantheon. Athame's worship gradually changed, becoming the basis for a monotheistic religion in which her maiden, matron, and matriarch aspects oversaw all stages and roles in asari society. When an asari says "by the goddess," they are referring to Athame. Worship of Athame eventually fell out of favor as the asari turned to the Siari religion. Along with her guides Janiri and Lucen, Athame is credited for helping to bring enlightenment to the ancient asari, with Janiri teaching them agricultural practices (including the seasons), Lucen teaching them about the stars, and Athame teaching them mathematics and medicine. The ancient asari also believed that Athame protected their homeworld Thessia from attacks by other, jealous gods. In reality, Athame was not a mythical goddess but a guise crafted by the Protheans. During the height of their empire, the Protheans discovered the asari and judged that they had potential as leaders for the races of the next cycle against the Reapers. They intervened in asari's development by creating the myth of a goddess, Athame, who was imparting divine gifts and knowledge through her guides, Janiri and Lucen, who were Protheans. Among those "gifts" was the asari's natural ability to develop biotics, which was, in reality, the product of years of Prothean genetic research and manipulation.